2006 Isuzu I 350 Recalls, Issues & Maintenance
The 2006 Isuzu I 350 carries 2 open NHTSA recalls — most recently covering switch. No recurring owner-reported issue clusters are on file. Isuzu stopped selling passenger vehicles in the United States after the 2008 model year, though its commercial truck business is still here, which means parts and knowledgeable service have not disappeared the way they did for some discontinued brands. One item matters more than everything else on this list. The 3.2 and 3.5 liter V6 in the Rodeo, Trooper, Amigo, Axiom, and VehiCross uses a rubber timing belt, and on the double overhead cam versions a broken belt bends valves. If you own one of these and cannot document the last belt change, that is the first call to make. The later models are easier: the Ascender is a Chevrolet TrailBlazer, the i-280 through i-370 are Chevrolet Colorados, the Hombre is an S-10, and the Oasis is a Honda Odyssey. For those, the donor brand's parts and specs apply.
2 Open Recalls
Source: NHTSAEXTERIOR LIGHTING:BRAKE LIGHTS:SWITCH
Campaign #06V139000 · Apr 27, 2006
EXTERIOR LIGHTING:BRAKE LIGHTS:SWITCH
Campaign #06V139000 · Apr 27, 2006
Issue: CERTAIN PICKUP TRUCKS MAY EXPERIENCE THE PERMANENT LOSS OF BRAKE LAMP FUNCTION OR BRAKE LAMPS THAT ARE ILLUMINATED AT ALL TIMES. THE CENTER HIGH-MOUNTED STOP LAMP (CHMSL) IS AFFECTED IN BOTH INSTANCES. ALSO, IF EQUIPPED, THE CRUISE CONTROL WILL BECOME INOPERATIVE. ANY TRAILER BRAKE LAMPS WHICH ARE CONNECTED TO THE VEHICLE'S BRAKE LAMP WIRING WILL MIMIC THE VEHICLE'S BRAKE LAMPS WHEN EITHER CONDITION OCCURS.
Risk: A FOLLOWING DRIVER MAY NOT KNOW WHEN THE BRAKES HAVE BEEN APPLIED, AND A REAR-END CRASH COULD OCCUR WITHOUT PRIOR WARNING.
Fix: DEALERS WILL REPLACE THE BRAKE LAMP SWITCH ASSEMBLY. THE RECALL BEGAN ON DECEMBER 5, 2006. OWNERS MAY CONTACT CHEVROLET AT 1-800-630-2438; GMC AT 1-866-996-9463 OR ISUZU AT 1-800-255-6727.
EXTERIOR LIGHTING:BRAKE LIGHTS:SWITCH
Campaign #09V310000 · Jul 29, 2009
EXTERIOR LIGHTING:BRAKE LIGHTS:SWITCH
Campaign #09V310000 · Jul 29, 2009
Issue: GM IS RECALLING 185,903 MODEL YEAR 2004-2009 COLORADO, GMC MODEL YEAR 2009-2004 CANYON, MODEL YEAR 2006 I-280, I-350, MODEL YEAR 2007-2008 I-290, AND I-370, PASSENGER VEHICLES ORIGINALLY SOLD IN OR CURRENTLY REGISTERED IN THE STATES OF ALABAMA, ARIZONA, FLORIDA, GEORGIA, HAWAII, LOUISIANA, MISSISSIPPI, NEVADA, NEW MEXICO, PUERTO RICO, SOUTH CAROLINA, TEXAS, U.S. VIRGIN ISLANDS AND UTAH. SOME OF THESE VEHICLES HAVE A BRAKE LAMP SWITCH THAT MAY NOT WORK AS DESIGNED DUE TO CONTAMINATION IN THE SWITCH.
Risk: THIS CONDITION COULD CAUSE THE SIMULTANEOUS LOSS OF ALL BRAKE LAMPS OR CAUSE ALL OF THE BRAKE LAMPS TO STAY ON CONTINUOUSLY. BOTH OF THESE CONDITIONS COULD FAIL TO WARN OTHERS OF THE DRIVER'S INTENTIONS AND COULD LEAD TO A VEHICLE CRASH.
Fix: DEALERS WILL INSPECT AND REPLACE THE NECESSARY COMPONENTS AS SPECIFIED IN THE RECALL BULLETIN FREE OF CHARGE. GM ANTICIPATES THAT PARTS WILL BE AVAILABLE BY JUNE 2010. A SPECIAL COVERAGE FOR VEHICLES REGISTERED IN ALL OTHER STATES WILL BE IMPLEMENTED IN THE SAME TIME FRAME. IN THE INTERIM, OWNERS WHO EXPERIENCE THE FAILURE CAN OBTAIN A FREE REPAIR, HOWEVER THEY WILL BE REQUIRED TO RETURN WHEN THE NEW DESIGN PART BECOMES AVAILABLE. OWNERS MAY CONTACT CHEVROLET AT 1-800-630-2438, GMC AT 1-866-996-9463, ISUZU AT 1-800-255-6727 OR AT WWW.GMOWNERCENTER.COM.
Known issues for this vehicle
What drivers and federal regulators have officially reported about the 2006 Isuzu I 350.
Reported to NHTSA
NHTSA has 4 complaints on file for the 2006 Isuzu I 350 (2006-04 → 2010-03). We haven't grouped them yet for this specific vehicle — for now, the full list lives on NHTSA.
Top reported components: EXTERIOR LIGHTING (2) · SERVICE BRAKES (1) · HYDRAULIC (1)
Note: NHTSA also opened 1 defect investigation(s) on this vehicle that closed without action.
Source: NHTSA Office of Defects Investigation (ODI). Complaint data refreshed Sep 18, 2026. Investigation data refreshed Sep 1, 2026.
We display NHTSA's record with attribution; we don't editorialize on what these complaints mean for any specific vehicle.
Essential maintenance
Critical for safety and preventing major damage
Timing Belt (3.2L and 3.5L V6)
Every 75,000 miReplace every 75,000 miles or 7 years on the V6 in the Rodeo, Trooper, Amigo, Axiom, and VehiCross. Do the water pump, tensioner, and idlers in the same job, because the labor is nearly all in the access. The double overhead cam version is an interference design, so a failed belt means bent valves rather than a tow. The 2.6 four and the GM and Honda sourced engines in the later rebadges use chains and are not on this schedule.
Estimated cost — typical U.S. ranges
Dealer
~$935–$1175
Shop
~$655–$825
DIY
Pro only
On interference engines, a snapped belt destroys valves. Worth doing on schedule. Bundle water pump + tensioner — labor is already there.
Engine Oil & Filter
Every 3,750 miIsuzu specified 3,750 miles under its severe schedule, which covers towing, short trips, and dusty roads. On engines this old, stay near that number and change at least once a year regardless of miles.
Estimated cost — typical U.S. ranges
Dealer
~$120–$160
Shop
~$85–$115
DIY
~$25–$55
Full synthetic costs more than conventional. 5-quart 0W-20 + filter is the typical bill.
Tire Rotation
Every 7,500 miRotate every 7,500 miles. On the Trooper, Rodeo, and Amigo, check the tailgate-mounted spare as well. Sun exposure ages it faster than the four tires carrying the truck.
Estimated cost — typical U.S. ranges
Dealer
~$85
Shop
~$60
DIY
Free
Often free at the shop where you bought the tires — worth asking before paying.
Brake Inspection
Every 7,500 miInspect pads, rotors, hoses, and hard lines at every service. These are heavy body-on-frame trucks with rear drums on many models, and drum hardware seizes on vehicles that sit.
Estimated cost — typical U.S. ranges
Dealer
~$85
Shop
~$60
DIY
Free
Most shops do this free as a courtesy with any service. Don't pay separately if you can avoid it.
Brake Fluid
Every 24,000 miReplace every 2 years. On a truck this old it is the cheapest way to protect the master cylinder, the calipers, and the ABS unit.
Estimated cost — typical U.S. ranges
Dealer
~$180–$200
Shop
~$125–$140
DIY
~$10–$25
DOT 3 or 4 — match the cap. Vacuum bleeders make this a one-person DIY.
Important maintenance
Keeps your vehicle running smoothly and efficiently
Transfer Case & Differential Fluid (4WD models)
Every 30,000 miChange every 30,000 miles, and right away after any deep water crossing. Front and rear differentials and the transfer case each hold their own fluid. Limited-slip rear axles need the friction modifier added when refilled.
Estimated cost — typical U.S. ranges
Dealer
~$105–$140
Shop
~$75–$100
DIY
~$15–$40
AWD/4WD vehicles only. Easy drain-and-fill on most platforms.
Automatic Transmission Fluid
Every 45,000 miDrain and fill every 45,000 miles, or every 30,000 if you tow. Fluid spec follows the drivetrain: Isuzu or Dexron III for the original models, Dexron VI for the GM based Ascender and i-series, and Honda fluid for the Oasis.
Estimated cost — typical U.S. ranges
Dealer
~$330–$500
Shop
~$235–$355
DIY
~$60–$180
Some sealed transmissions have no dipstick — fill is precise and best left to a shop. Many drivers can still DIY drain-and-fill.
Spark Plugs
Every 60,000 miAround 60,000 miles on conventional plugs, up to 100,000 on platinum. Rear bank access on the V6 is tight, so this is often worth pairing with other top-end work.
Estimated cost — typical U.S. ranges
Dealer
~$285–$390
Shop
~$200–$275
DIY
~$25–$100
Iridium plugs cost more but last 100k+ miles. V6/V8 access varies wildly — some are tough.
Engine Air Filter
Every 30,000 miReplace every 30,000 miles, or every 15,000 if the truck sees dirt roads or trail use.
Estimated cost — typical U.S. ranges
Dealer
~$60–$95
Shop
~$45–$70
DIY
~$15–$40
5-minute job on most cars; the airbox lid usually has clips, no tools needed.
Recommended maintenance
Extends the life of your vehicle and improves comfort
Coolant Replacement
Every 60,000 miEvery 3 to 5 years. If the timing belt is being done, do the coolant at the same visit, since the water pump comes out either way. Ask the shop to check the radiator and heater hoses while it is drained.
Estimated cost — typical U.S. ranges
Dealer
~$285–$330
Shop
~$200–$235
DIY
~$25–$60
Use the manufacturer-specified coolant — wrong color/chemistry can damage the cooling system.
Battery & Charging System Test
Every 25,000 miTest the battery and alternator once a year and clean the ground straps. Frame grounds corrode on trucks of this age and cause faults that look electrical but are only dirty connections.
Estimated cost — typical U.S. ranges
Dealer
~$225–$390
Shop
~$160–$280
DIY
~$130–$250
Most auto-parts stores test and install batteries free with purchase. Skip the dealer markup.
Typical U.S. ranges. Actual quotes vary by shop, parts choice, and vehicle condition.
How we estimate: Dealer = OEM parts × 1.4 + labor × $165/hr. Shop = parts + labor × $115/hr. DIY = parts only.
This maintenance schedule for the 2006 Isuzu I 350 reflects Isuzu's published service intervals. Your actual service needs may vary based on driving conditions, climate, and vehicle usage. Always consult your owner's manual for model-specific recommendations.