2021 Mercedes Benz E Class Recalls, Issues & Maintenance

The 2021 Mercedes Benz E Class has no open NHTSA recalls. Owners report 6 recurring issue clusters, led by “Engine misfire and cylinder failure with power loss.” Mercedes-Benz alternates two service events: Service A (oil, filter, inspection) at roughly 10,000 miles or 1 year, then Service B (Service A plus brake fluid, cabin filter, and deeper checks) at roughly 20,000 miles or 2 years — the ASSYST Plus counter in the cluster tells you which is due. Oil must carry the MB-Approval number your engine specifies (commonly 229.5, or 229.71 for newer 0W-20 engines); 'meets or exceeds' marketing language is not an approval. Electric EQB and EQS models keep the A/B rhythm for inspections, brake fluid, and cabin filters — just without oil.

No open recalls on file. NHTSA lists no unrepaired safety recalls for this year, make and model. A recall can be issued at any time, and a specific car can still have one open — check yours by VIN at nhtsa.gov/recalls.

Known issues for this vehicle

What drivers and federal regulators have officially reported about the 2021 Mercedes Benz E Class.

Reported to NHTSA

Engine misfire and cylinder failure with power loss

ENGINE

4 NHTSA complaints · 2024-02-09 → 2026-08-08

My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines
Owner report, NHTSA ODI #11673376
The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power
Owner report, NHTSA ODI #11571057

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48-volt battery failure and vehicle inoperability

ELECTRICAL SYSTEM:12V/24V/48V BATTERY

5 NHTSA complaints · 2021-04-07 → 2026-01-04

The 48 volt battery on this mild hybrid vehicle failed and the car was unable to be started on May 3, 2021, with 196 miles on the odometer, a mere 15 days after delivery. It had to be taken by flatbed to the dealer where ultimately the 48 volt battery was replaced. Then again…
Owner report, NHTSA ODI #11441712
TL* THE CONTACT OWNS A 2021 MERCEDES-BENZ E450. THE CONTACT STATED THAT WHILE STATIONARY, THE INSTRUMENT PANEL DISPLAYED A MESSAGE INDICATING THAT THE VEHICLE HAD CRASHED. AFTER THE MESSAGE WAS DISPLAYED, THE VEHICLE LOSS MOTIVE POWER. THE VEHICLE WAS TOWED TO MERCEDES-BENZ OF…
Owner report, NHTSA ODI #11406950

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Transmission failure while driving

POWER TRAIN

2 NHTSA complaints · 2025-07-10 → 2026-01-04

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded
Owner report, NHTSA ODI #11672435
With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure
Owner report, NHTSA ODI #11708688

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Rearview camera and parking sensor inoperative display

BACK OVER PREVENTION: SENSING SYSTEM: CAMERA, BACK OVER PREVENTION: WARNINGS

4 NHTSA complaints · 2021-09-02 → 2024-05-18

I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says…
Owner report, NHTSA ODI #11589422
When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash
Owner report, NHTSA ODI #11560848

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Automatic emergency braking unintended activation

FORWARD COLLISION AVOIDANCE: AUTOMATIC EMERGENCY BRAKING

2 NHTSA complaints · 2020-11-06 → 2022-12-15

I was driving on a local road (paved, no painted road markings, some small cracks/pot holes but all minor) that I frequently drive without issue. This time as I was coming out of a minor left-hand curve and about 30 meters from a slightly sharper right hand turn the Automatic…
Owner report, NHTSA ODI #11497646
WHILE GOING 45 MPH ON A CLEAR FOUR LANE SMOOTH BLACKTOP CITY STREET THE CAR CAME TO A COMPLETE EMERGENCY STOP. A RED TRIANGLE APPEARED ON THE DASH BUT BECAUSE OF THE STARTLING NATURE I COULD NOT REMEMBER EXACTLY WHERE. THERE WAS NO APPARENT REASON FOR THIS EMERGENCY STOP
Owner report, NHTSA ODI #11373428

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12V battery warning followed by vehicle fire

ENGINE, ELECTRICAL SYSTEM

1 NHTSA complaint · 2024-12-07 → 2024-12-07

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left
Owner report, NHTSA ODI #11629406

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Source: NHTSA Office of Defects Investigation (ODI). Complaint data refreshed Sep 17, 2026. Investigation data refreshed Sep 17, 2026.

We display NHTSA's record with attribution; we don't editorialize on what these complaints mean for any specific vehicle.

Essential maintenance

Critical for safety and preventing major damage

Service A — Oil & Filter + Inspection

Every 10,000 mi

Every 10,000 miles or 12 months: oil and filter with MB-Approved oil, fluid top-offs, tire check, and inspection. AMG models driven hard: many owners service at 5,000-7,500 miles.

Estimated cost — typical U.S. ranges

Dealer

~$120–$160

Shop

~$85–$115

DIY

~$25–$55

Full synthetic costs more than conventional. 5-quart 0W-20 + filter is the typical bill.

Service B — Major Inspection

Every 20,000 mi

Every 20,000 miles or 2 years, alternating with Service A: everything in A plus brake-fluid replacement, cabin filter, and a deeper multi-point inspection of brakes, suspension, and driveline.

Estimated cost — typical U.S. ranges

Dealer

~$85

Shop

~$60

DIY

Free

Most shops do this free with any paid service. A flashlight and 10 minutes covers the basics yourself.

Tire Rotation

Every 10,000 mi

Rotate at every Service A where the tire sizes allow. Many AMG and 4MATIC+ models run staggered widths that can't rotate front-to-rear — check your spec before paying for a rotation.

Estimated cost — typical U.S. ranges

Dealer

~$85

Shop

~$60

DIY

Free

Often free at the shop where you bought the tires — worth asking before paying.

Brake Inspection

Every 10,000 mi

Checked at every A/B service via electronic pad-wear sensors. Replace sensors with pads. Heavy EQS models wear pads slowly (regen braking) but rotors can corrode from disuse — an inspection catches that.

Estimated cost — typical U.S. ranges

Dealer

~$85

Shop

~$60

DIY

Free

Most shops do this free as a courtesy with any service. Don't pay separately if you can avoid it.

Brake Fluid

Every 20,000 mi

Replaced every 2 years as part of Service B — Mercedes schedules it on time, not miles, because DOT 4 fluid absorbs moisture regardless of driving.

Estimated cost — typical U.S. ranges

Dealer

~$180–$200

Shop

~$125–$140

DIY

~$10–$25

DOT 3 or 4 — match the cap. Vacuum bleeders make this a one-person DIY.

Important maintenance

Keeps your vehicle running smoothly and efficiently

Automatic Transmission Fluid (7G / 9G-Tronic)

Every 70,000 mi

Mercedes specifies fluid and filter service around 70,000 miles on most 7G- and 9G-Tronic gearboxes — check your year's sheet. Use only the MB-spec fluid for your transmission code; independent specialists often service at 60,000 on hard-driven cars.

Estimated cost — typical U.S. ranges

Dealer

~$330–$500

Shop

~$235–$355

DIY

~$60–$180

Some sealed transmissions have no dipstick — fill is precise and best left to a shop. Many drivers can still DIY drain-and-fill.

Spark Plugs

Every 60,000 mi

Most modern MB gas engines: plugs around 60,000 miles — AMG engines often sooner. Check your engine's sheet; twin-turbo V8 plug jobs are labor-heavy, so pair with other scheduled work.

Estimated cost — typical U.S. ranges

Dealer

~$285–$390

Shop

~$200–$275

DIY

~$25–$100

Iridium plugs cost more but last 100k+ miles. V6/V8 access varies wildly — some are tough.

Engine Air Filter

Every 40,000 mi

Replace around every 40,000 miles (twin-filter setups on V6/V8 engines double the parts bill). Inspected at every Service B.

Estimated cost — typical U.S. ranges

Dealer

~$60–$95

Shop

~$45–$70

DIY

~$15–$40

5-minute job on most cars; the airbox lid usually has clips, no tools needed.

Recommended maintenance

Extends the life of your vehicle and improves comfort

Combination / Dust Filter

Every 20,000 mi

Replaced with every Service B. Models with the ENERGIZING air package use a higher-grade filter — priced accordingly.

Estimated cost — typical U.S. ranges

Dealer

~$60–$95

Shop

~$45–$70

DIY

~$15–$40

Usually behind the glovebox. Shops charge labor for a 10-minute job — easy DIY win.

Engine Coolant

On condition / lifetime

MB-spec coolant is long-life (typically ~10 years / 150,000 miles on the sheet). Refresh only with MB 325/326-spec coolant — the wrong chemistry attacks aluminum and head gaskets.

Estimated cost — typical U.S. ranges

Dealer

~$285–$330

Shop

~$200–$235

DIY

~$25–$60

Use the manufacturer-specified coolant — wrong color/chemistry can damage the cooling system.

12V & Auxiliary Battery

Every 25,000 mi

Test annually after year 3. Most modern Mercedes carry a second auxiliary battery; a weak one triggers cascading warning messages long before a no-start. EQ models also depend on the 12V system to boot.

Estimated cost — typical U.S. ranges

Dealer

~$225–$390

Shop

~$160–$280

DIY

~$130–$250

Most auto-parts stores test and install batteries free with purchase. Skip the dealer markup.

Fatal crash history & reported problems

Occupant deaths in fatal crashes (FARS)

5 crashes 2010–2024

FARS counts every occupant death in a fatal crash, whatever the cause — it does not mean the vehicle was at fault or defective. Counts are not adjusted for how many of each vehicle are on the road. How to read this number

Owner-reported problem signals

Separate from the federal fatality data above: complaints owners filed with NHTSA about this year and model. These are reports of problems, unverified, and are counted here only as signals.

0

complaints mentioning a crash

1

complaints mentioning a fire

Reviewed known issues for this vehicle

Typical U.S. ranges. Actual quotes vary by shop, parts choice, and vehicle condition.

How we estimate: Dealer = OEM parts × 1.4 + labor × $165/hr. Shop = parts + labor × $115/hr. DIY = parts only.

This maintenance schedule for the 2021 Mercedes Benz E Class reflects Mercedes-Benz's published service intervals and the ASSYST Plus (Service A / Service B) system. Your actual service needs may vary based on driving conditions, climate, and vehicle usage. Always consult your owner's manual for model-specific recommendations.